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何秀苗

发布日期:2022-09-07 来源:  作者: 浏览次数:

    




基本情况

何秀苗,博士,教授,硕士生导师。为广西民族大学生物学学科方向负责人,生物技术专业负责人,相思湖青年学者创新团队负责人,兼任广西畜牧兽医学会养禽与禽病学分会副理事长,第七届中国免疫学学会兽医免疫学分会委员,“湾区认证”农食委专家委员,广西动物疫病净化专家等。


科研方向

动物病原生物学及免疫学,主要涉及以下两个方面:

(1)病原生物学、分子流行病学研究、疫病防控技术

(2)病原与宿主相互作用


联系方式

邮箱:xiumiaohe0839@sina.com


教育经历

2001/9 - 2004/7,扬州大学,预防兽医学,博士

1994/9 - 2001/7,广西大学,预防兽医学,学士,硕士


工作经历

2011/7 - 至今,广西民族大学,海洋与生物技术学院生物技术系,教授

2017/9-2018/9 University of Michigan(Ann Arbor, USA) 医学院微生物与免疫学系 访问学者

2011/1 -2011/12  University of Michigan(Ann Arbor, USA) 医学院微生物与免疫学系 访问学者

2009/12 - 2011/6,广西民族大学,化学与生态工程学院生物技术系,教授

2004/7 - 2009/11,广西民族大学,化学与生态工程学院生物技术系,副教授


讲授课程

细胞生物学;分子生物学;基因工程;生物技术大实验;动物生理学


科研项目(主持)

1)国家自然科学基金,传染性法氏囊病病毒通过控制宿主肠道菌群促进其体内复制的分子机制,2025/01-2028/12,32万,在研

2)国家自然科学基金,传染性法氏囊病病毒通过凋亡Caspase调控IRF7降解促进免疫逃逸的分子机制,2022/01/-2025/12,35万,在研

3)国家自然科学基金,传染性法氏囊病病毒调节IRF3信号通路促进胞内复制的分子机制,2016/01-2019/12,47.6万,结题

4)广西自然科学基金面上项目, 海洋弧菌BHc-09 EPS调控IBDV复制的分子机制,2017/09-2020/09,12万,结题

5)广西自然科学基金重点项目,广西鸡传染性法氏囊病病毒流行株基因型多样性及其抗原性研究,2014/05-2017/05,30万,在研,主持人

6)广西民族大学相思湖青年学者创新团队项目“广西北部湾生物资源开发与利用”,2015/01-2017/12,30万,结题

7)广西高校科研项目,2013YB069、不同基因型鸡传染性法氏囊病病毒生物学特性研究,2013/05-2016/05,3万,结题

8)广西自然科学基金面上项目,广西鸡传染性法氏囊病病毒野毒株的基因分型及代表株的抗原变异情况研究,2012/05-2015/05,4万,结题



获奖情况

1)何秀苗(4/15). 地方品种鸡“两白”净化防控技术创新与应用,广西科技进步奖二等奖,2024年

2)何秀苗(7/10). 广西优质鸡马立克氏病防控关键技术创新及集成应用,广西科技进步奖二等奖,2018年

3)何秀苗(7/16). 广西优质鸡马立克氏病防控关键技术创新及集成应用,广西科技进步奖二等奖,2018年

4)何秀苗. 第一届广西畜牧兽医青年科技奖. 广西畜牧兽医学会. 2018年

5)何秀苗(4/7). 鸡肿瘤病快速鉴别诊断技术的研究与应用, 广西科技进步奖二等奖,2006



发明专利

1)传染性法氏竞病病毒重组融合蛋白VP2-VP1及其制备方法和应用. 中国发明专利,2020年. 专利号:ZL2016 1 0389727.2

2)重组传染性法氏寰病病毒毒株及其制备方法. 中国发明专利,2021年, 专利号: ZL 2019 1 0496396.6

3)一种重组禽腺病毒的制备方法. 中国发明专利,2005年,专利号ZL03131899.1

4)传染性法氏囊病病毒快速分型分析系统V1.0. 计算机软件著作权, 2021年, 登记号2021SR0600005

5)规模化鸡场疫病诊疗及防治技术远程服务平台V1.0. 计算机软件著作权, 2021年, 登记号2021SR0600968

6)规模化养禽场环境污染监测及治理评估辅助平台V1.0. 计算机软件著作权, 2021年, 登记号2021SR0601552

7)鸡场主要疫病抗体监测及分析系统V1.0. 计算机软件著作权, 2021年, 登记号2021SR0600004



1)《重要动物病毒分子生物学》(何秀苗负责“禽腺病毒”一章) 韦 平,秦爱建主编,科学出版社, 2008年

2)《动物病毒反向遗传学》(何秀苗负责“腺病毒载体构建”一章).刘光清主编,科学出版社, 2009年

3)《兽医全攻略——鸡病》(何秀苗负责“鸡传染性法氏囊病”一章). 崔治中主编,中国农业出版社, 2009年.

4)《中国禽病学》(第2版)(何秀苗负责“鸡传染性法氏囊病”一章).刘金华,甘孟侯主编,中国农业出版社,2016年



近5年代表性论文

1. Wang Z, Chen Y, Chen Y, Chen R, Wang W, Hu S, Li Y, Chen H, Wei P, He X*. Infectious bursal disease virus affecting interferon regulatory factor 7 signaling through VP3 protein to facilitate viral replication. Front Cell Infect Microbiol. 2025, 14:1529159.

2. Chen J, Wang W, Li S, Wang Z, Zuo W, Nong T, Li Y, Liu H, Wei P, He X*. RNA-seq reveals role of cell-cycle regulating genes in the pathogenicity of a field very virulent infectious bursal disease virus. Front Vet Sci. 2024, 11:1334586.

3. Wang W, Zhang Y, Zuo W, Qiao Y, Shi J, Huang J, Huang T, Wei T, Mo M, He X*, Wei P. Rapid identification, pathotyping and quantification of infectious bursal disease virus by high-resolution melting curve quantitative reverse transcription PCR analysis: An innovative technology well-suited for real-time large-scale epidemiological surveillance. Poult Sci. 2024, 103(12):104440.

4. Wang W, Huang Y, Zhang Y, Qiao Y, Shi J, Huang J, Huang T, Wei T, Mo M, He X*, Wei P. The complete protections induced by the oil emulsion vaccines of the novel variant infectious bursal disease viruses against the homologous challenges indicating the important roles of both VP2 and VP1 in the antigenicity and pathogenicity of the virus.Front Vet Sci. 2024, 11:1466099.

5. Wang W, Shi J, Zhang Y, Qiao Y, Zuo W, Wang Z, Nong T, Hu S, Chen Y, Kong R, He X*, Wei P. Genetic and pathogenic characterizations of a naturally occurring reassortant and homologous recombinant strain of the classical infectious bursal disease virus re-emerging in chickens in southern China. Front Microbiol. 2023, 14:1293072.

6. Chen R, Chen J, Xiang Y, Chen Y, Shen W, Wang W, Li Y, Wei P, He X*. Differential Modulation of Innate Antiviral Profiles in the Intestinal Lamina Propria Cells of Chickens Infected with Infectious Bursal Disease Viruses of Different Virulence. Viruses, 2022, 14(2):393.

7. Wang W, Huang Y, Zhang Y, Qiao Y, Deng Q, Chen R, Chen J, Huang T, Wei T, Mo M, He X*, Wei P. The emerging naturally reassortant strain of IBDV (genotype A2dB3) having segment A from Chinese novel variant strain and segment B from HLJ 0504-like very virulent strain showed enhanced pathogenicity to three-yellow chickens. Transbound Emerg Dis. 2021, doi: 10.1111/tbed.14336.

8. Wang W, Huang Y, Ji Z, Chen G, Zhang Y, Qiao Y, Shi M, Li M, Huang T, Wei T, Mo M, He X*, Wei P. The Full Region of N-Terminal in Polymerase of IBDV Plays an Important Role in Viral Replication and Pathogenicity: Either Partial Region or Single Amino Acid V4I Substitution Does Not Completely Lead to the Virus Attenuation to Three-Yellow Chickens. Viruses, 2021, 13(1): 107.

9. Wang W, Zhang Y, Huang Y, Chen G, Shi M, Qiao Y, Huang T, Wei T, Mo M, He X*, Wei P. Rapid and visual detection of the emerging novel duck reovirus by using a specific and sensitive reverse transcription recombinase polymerase amplification method. J Virol Methods, 2021, 291:114098. doi: 10.1016/j.jviromet.2021.114098.

10. Wang W, Liang J, Shi M, Chen G, Huang Y, Zhang Y, Zhao Z, Wang M, Li M, Mo M, Wei T, Huang T, He X*, Ping Wei. The diagnosis and successful replication of a clinical case of Duck Spleen Necrosis Disease: An experimental co-infection of an emerging unique reovirus and Salmonella indiana reveals the roles of each of the pathogens. Veterinary Microbiology 2020, 246:108723. https://doi.org/10.1016/j.vetmic.2020.108723

11. Xu J, Neal LM, Ganguly A, Kolbe JL, Hargarten JC, Elsegeiny W, Hollingsworth C, He X, Ivey M, Lopez R, Zhao J, Segal B, Williamson PR, Olszewski MA. Chemokine receptor CXCR3 is required for lethal brain pathology but not pathogen clearance during cryptococcal meningoencephalitis. Sci Adv. 2020, 6(25):eaba2502.

12.He X, Wang W, Chen G, Jiao P, Ji Z, Yang L, Wei P*. Serological study reveal different antigenic IBDV strains prevalent in southern China during the years 2000-2017 and also the antigenic differences between the field strains and the commonly used vaccine strains. Veterinary Microbiology. 2019, 239:108458. doi: 10.1016/j.vetmic.2019.108458

13. Chen Guo, He X*, Yang Lin, Wei P. Antigenicity characterization of four representative natural reassortment IBDVs isolated from commercial three-yellow chickens from Southern China reveals different subtypes co-prevalent in the field. Veterinary Microbiology, 2018, 219:183-189;

14. He X, Chen Yanyan, Kang Synat, Chen Guo, Wei P. Differential Regulation of chTLR3 by Infectious Bursal Disease Viruses with Different Virulence In Vitro and In Vivo. Viral Immunol. 2017, 30(7):490-499

15. 李尚泉,何秀苗*,韦 平. 传染性法氏囊病病毒先天性免疫分子机制研究进展. 中国家禽,2020, 42(12):87-95

16. 王威威,刘婷,陈果,姬忠华,赵增志,黄宇,陈艳艳,石梦雅,何秀苗*,韦平. 传染性法氏囊病病毒主要结构蛋白VP2、VP1 和VP2-VP1串联基因的原核表达及其初步应用. 畜牧与兽医,2020,52 ( 5) : 73-80.